Target
Tumor necrosis factor
Ligand
BDBM395758
Substrate
n/a
Meas. Tech.
TNF induced HEK-Blue assay
IC50
<1000±n/a nM
Citation
 Wrobleski, STBrown, GDLin, SDuan, JLu, ZDhar, MTXiao, HTebben, AJ Tricyclic heterocyclic compounds useful as inhibitors of TNF US Patent  US10308652 Publication Date 6/4/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM395758
Synonyms:
US10308652, Example 39
Type:
Small organic molecule
Emp. Form.:
C25H22F4N4O2
Mol. Mass.:
486.4614
SMILES:
CC(C)(O)c1ccc(cc1)-c1ccc2nc3[C@@H](O)CN[C@@H](c3n2n1)c1ccc(F)cc1C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: