Target
Tumor necrosis factor
Ligand
BDBM395764
Substrate
n/a
Meas. Tech.
TNF induced HEK-Blue assay
IC50
5500±n/a nM
Citation
 Wrobleski, STBrown, GDLin, SDuan, JLu, ZDhar, MTXiao, HTebben, AJ Tricyclic heterocyclic compounds useful as inhibitors of TNF US Patent  US10308652 Publication Date 6/4/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM395764
Synonyms:
US10308652, Example 45
Type:
Small organic molecule
Emp. Form.:
C26H25F2N5O3
Mol. Mass.:
493.5052
SMILES:
O[C@H]1CN[C@@H](c2c1nc1ccc(nn21)-c1ccc(cc1)N1CCOCC1)c1ccccc1OC(F)F |r|
Structure:
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