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Target
Tumor necrosis factor
Ligand
BDBM395777
Substrate
n/a
Meas. Tech.
TNF induced HEK-Blue assay
IC50
<1000±n/a nM
Citation
 Wrobleski, ST; Brown, GD; Lin, S; Duan, J; Lu, Z; Dhar, MT; Xiao, H; Tebben, AJ Tricyclic heterocyclic compounds useful as inhibitors of TNF US Patent  US10308652 Publication Date 6/4/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM395777
Synonyms:
Cis-9-(2-(difluoromethoxy)phenyl)-2-(4-(2-hydroxypropan-2-yl)phenyl)-6,9-dihydro-7H-pyrano[4′,3′:4,5]imidazo[1,2-b]pyridazin-6-ol | US10308652, Example 58
Type:
Small organic molecule
Emp. Form.:
C25H23F2N3O4
Mol. Mass.:
467.4646
SMILES:
CC(C)(O)c1ccc(cc1)-c1ccc2nc3[C@@H](O)CO[C@H](c3n2n1)c1ccccc1OC(F)F |r|
Structure:
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