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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM396046
Substrate
n/a
Meas. Tech.
SHP2 Allosteric Inhibition Assay
IC50
43.0±n/a nM
Citation
 Chen, Z; Fortanet, JG; LaMarche, MJ; Sendzik, M; Tamez, Jr., V; Yu, B Compounds and compositions for inhibiting the activity of SHP2 US Patent  US10308660 Publication Date 6/4/2019 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM396046
Synonyms:
US10308660, Example 148
Type:
Small organic molecule
Emp. Form.:
C21H24Cl2F3N5O
Mol. Mass.:
490.349
SMILES:
Cn1c(nc(N)c(-c2cccc(Cl)c2Cl)c1=O)N1CCC2(C[C@H](C[C@H]2N)C(F)(F)F)CC1 |r,wU:24.27,22.28,(-.08,-1.7,;-1.42,-.93,;-1.42,.61,;-2.75,1.38,;-4.08,.61,;-5.42,1.38,;-4.08,-.93,;-5.42,-1.7,;-6.75,-.93,;-8.08,-1.7,;-8.08,-3.24,;-6.75,-4.01,;-6.75,-5.55,;-5.42,-3.24,;-4.08,-4.01,;-2.75,-1.7,;-2.75,-3.24,;-.08,1.38,;1.25,.61,;2.58,1.38,;2.58,2.92,;2.75,4.46,;4.25,4.78,;5.02,3.44,;3.99,2.3,;1.66,5.55,;4.88,6.18,;5.5,7.59,;6.28,5.56,;3.47,6.81,;1.25,3.69,;-.08,2.92,)|
Structure:
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