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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM30188
Substrate
HSP27 Peptide
Meas. Tech.
MK-2 IC50 Value Determination
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
21±1 nM
Citation
 Anderson, DR; Meyers, MJ; Vernier, WF; Mahoney, MW; Kurumbail, RG; Caspers, N; Poda, GI; Schindler, JF; Reitz, DB; Mourey, RJ Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem 50:2647-54 (2007) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM30188
Synonyms:
Pyrrolopyridine, 19
Type:
Small organic molecule
Emp. Form.:
C18H15N3O2
Mol. Mass.:
305.3306
SMILES:
Oc1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
HSP27 Peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1389.69
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
KKKALSRNLSVAA