Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [349-460]
Ligand
BDBM50427457
Substrate
n/a
Meas. Tech.
in vitro kinase inhibition assay
IC50
628±n/a nM
Citation
 Durden, DL; Morales, GA; Garlich, JR Thienopyranones as kinase and epigenetic inhibitors US Patent  US10308662 Publication Date 6/4/2019 
Target
Name:
Bromodomain-containing protein 4 [349-460]
Synonyms:
BRD4 | BRD4 bromodomain 2 | BRD4_HUMAN | Brd4-2 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13087.06
Organism:
Homo sapiens (Human)
Description:
O60885[349-460]
Residue:
112
Sequence:
KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM50427457
Synonyms:
CHEMBL2326952 | US10308662, Compound 25 | US9505780, 25
Type:
Small organic molecule
Emp. Form.:
C20H19NO5S
Mol. Mass.:
385.434
SMILES:
CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: