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Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM259884
Substrate
n/a
Meas. Tech.
in vitro kinase inhibition assay
IC50
1012±n/a nM
Citation
 Durden, DL; Morales, GA; Garlich, JR Thienopyranones as kinase and epigenetic inhibitors US Patent  US10308662 Publication Date 6/4/2019 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM259884
Synonyms:
US10308662, Compound 125 | US9505780, 125
Type:
Small organic molecule
Emp. Form.:
C20H19NO4S2
Mol. Mass.:
401.499
SMILES:
CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCSCC1
Structure:
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