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Target
Bromodomain-containing protein 4 [44-167]
Ligand
BDBM259887
Substrate
n/a
Meas. Tech.
in vitro kinase inhibition assay
IC50
4002±n/a nM
Citation
 Durden, DL; Morales, GA; Garlich, JR Thienopyranones as kinase and epigenetic inhibitors US Patent  US10308662 Publication Date 6/4/2019 
Target
Name:
Bromodomain-containing protein 4 [44-167]
Synonyms:
BRD4 | BRD4 bromodomain 1 | BRD4_HUMAN | Brd4-1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14738.39
Organism:
Homo sapiens (Human)
Description:
O60885[44-167]
Residue:
124
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
  
Inhibitor
Name:
BDBM259887
Synonyms:
US10308662, Compound 128 | US9505780, 128
Type:
Small organic molecule
Emp. Form.:
C19H15NO3S
Mol. Mass.:
337.392
SMILES:
O=c1cc(oc2c(csc12)C#Cc1ccccc1)N1CCOCC1
Structure:
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