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Target
Ghrelin O-acyltransferase
Ligand
BDBM396192
Substrate
n/a
Meas. Tech.
hGOAT Activity in HEK293 Cells after Incubation
IC50
0.082±n/a nM
Citation
 Godbout, C; Trieselmann, T; Vintonyak, V Oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors US Patent  US10308667 Publication Date 6/4/2019 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
  
Inhibitor
Name:
BDBM396192
Synonyms:
6-[5-Bromo-6-(3-methyl-oxetan-3-ylmethoxy)-pyridin-2-ylmethyl]-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-7-ylamine | US10308667, Example 95
Type:
Small organic molecule
Emp. Form.:
C17H18BrN5O3
Mol. Mass.:
420.261
SMILES:
Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCC2(C)COC2)n1
Structure:
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