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Target
Ghrelin O-acyltransferase
Ligand
BDBM396213
Substrate
n/a
Meas. Tech.
hGOAT Activity in HEK293 Cells after Incubation
IC50
0.830±n/a nM
Citation
 Godbout, C; Trieselmann, T; Vintonyak, V Oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors US Patent  US10308667 Publication Date 6/4/2019 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
  
Inhibitor
Name:
BDBM396213
Synonyms:
6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-6-ylmethyl)-3-(2,2-difluoro-ethoxy)-pyridine-2-carbonitrile | US10308667, Example 116
Type:
Small organic molecule
Emp. Form.:
C15H12F2N6O2
Mol. Mass.:
346.2916
SMILES:
Cc1nc2nonc2c(N)c1Cc1ccc(OCC(F)F)c(n1)C#N
Structure:
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