Reaction Details Report a problem with these data
Target
Serine protease HTRA1
Ligand
BDBM396350
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
10.00±n/a nM
Citation
 Hornsperger, B; Iacone, R; Kuhn, B; Maerki, HP; Mohr, P; Reutlinger, M Trifluoromethylpropanamide derivatives US Patent  US9980929 Publication Date 5/29/2018 
Target
Name:
Serine protease HTRA1
Synonyms:
HTRA | HTRA1 | HTRA1_HUMAN | PRSS11
Type:
Protein
Mol. Mass.:
51293.95
Organism:
Homo sapiens (Human)
Description:
Q92743
Residue:
480
Sequence:
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
  
Inhibitor
Name:
BDBM396350
Synonyms:
US9980929, Example 50
Type:
Small organic molecule
Emp. Form.:
C24H23Cl2F3N2O4
Mol. Mass.:
531.352
SMILES:
COc1cccc(c1)[C@H](NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: