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Target
Serine protease HTRA1
Ligand
BDBM396357
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
59.0±n/a nM
Citation
 Hornsperger, B; Iacone, R; Kuhn, B; Maerki, HP; Mohr, P; Reutlinger, M Trifluoromethylpropanamide derivatives US Patent  US9980929 Publication Date 5/29/2018 
Target
Name:
Serine protease HTRA1
Synonyms:
HTRA | HTRA1 | HTRA1_HUMAN | PRSS11
Type:
Protein
Mol. Mass.:
51293.95
Organism:
Homo sapiens (Human)
Description:
Q92743
Residue:
480
Sequence:
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
  
Inhibitor
Name:
BDBM396357
Synonyms:
US9980929, Example 59
Type:
Small organic molecule
Emp. Form.:
C27H30Cl2F3N3O5S
Mol. Mass.:
636.51
SMILES:
CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@@H](N1CCS(=O)(=O)CC1)c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)F |r|
Structure:
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