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Target
Serine protease HTRA1
Ligand
BDBM396375
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
345±n/a nM
Citation
 Hornsperger, B; Iacone, R; Kuhn, B; Maerki, HP; Mohr, P; Reutlinger, M Trifluoromethylpropanamide derivatives US Patent  US9980929 Publication Date 5/29/2018 
Target
Name:
Serine protease HTRA1
Synonyms:
HTRA | HTRA1 | HTRA1_HUMAN | PRSS11
Type:
Protein
Mol. Mass.:
51293.95
Organism:
Homo sapiens (Human)
Description:
Q92743
Residue:
480
Sequence:
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
  
Inhibitor
Name:
BDBM396375
Synonyms:
US9980929, Example 77
Type:
Small organic molecule
Emp. Form.:
C24H24F3N3O5
Mol. Mass.:
491.4597
SMILES:
COc1ccc(cc1)[C@H](NC(=O)COc1cccc(c1)C#N)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F |r|
Structure:
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