Reaction Details Report a problem with these data
Target
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Ligand
BDBM263620
Substrate
n/a
Meas. Tech.
Submitochondrial Particle Assay
pH
7.4±n/a
IC50
>1000±n/a nM
Comments
extracted
Citation
 Cesati, RR; Radeke, HS; Pandey, SK; Purohit, A; Robinson, SP Compositions, methods, and systems for the synthesis and use of imaging agents US Patent  US9713651 Publication Date 7/25/2017 
Target
Name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Synonyms:
CI-51kD | Complex I-51kD | NADH dehydrogenase flavoprotein 1 | NADH-ubiquinone oxidoreductase 51 kDa subunit | NDUFV1 | NDUV1_BOVIN | UQOR1
Type:
PROTEIN
Mol. Mass.:
50659.85
Organism:
Bos taurus
Description:
EBI_100771
Residue:
464
Sequence:
MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRGDWYKTKEILLKGPDWILGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNNPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALIQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQQFAQQHQARQAAF
  
Inhibitor
Name:
BDBM263620
Synonyms:
4-chloro-2-cyclohexyl-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one | US9713651, 8
Type:
Small organic molecule
Emp. Form.:
C21H29FN2O3
Mol. Mass.:
376.465
SMILES:
CC(C)c1c(OCc2ccc(COCCF)cc2)cnn(c1=O)C(C)(C)C
Structure:
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