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Target
Ribosomal protein S6 kinase beta-1
Ligand
BDBM369757
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<25±n/a nM
Citation
 Huck, BR; Lan, R; Potnick, J; Deselm, LC; Cronin, Jr., MW; Neagu, C; Chen, X; Boivin, R; Johnson, TL; Goutopoulos, A Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors US Patent  US9981925 Publication Date 5/29/2018 
Target
Name:
Ribosomal protein S6 kinase beta-1
Synonyms:
70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1
Type:
Enzyme
Mol. Mass.:
59139.89
Organism:
Homo sapiens (Human)
Description:
His-tagged S6K1.
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM369757
Synonyms:
US10233160, Compound 48 | US9981925, Compound 48
Type:
Small organic molecule
Emp. Form.:
C20H19F3N6O
Mol. Mass.:
416.3997
SMILES:
NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(F)c(c3)C(F)F)ncnc12 |r|
Structure:
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