Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [588-1147,K652R,M771V]
Ligand
BDBM77092
Substrate
n/a
Meas. Tech.
PHENOSENSE assay
IC50
1.8±0.0 nM
Citation
 Lanier, ER Methods of treating retroviral infections and related dosage regimes US Patent  US9694024 Publication Date 7/4/2017 
Target
Name:
Gag-Pol polyprotein [588-1147,K652R,M771V]
Synonyms:
HIV RT (65R/184V) | POL_HV1H2 | gag-pol
Type:
n/a
Mol. Mass.:
64482.36
Organism:
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)
Description:
P04585[588-1147,K652R,M771V]
Residue:
560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKRKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVL
  
Inhibitor
Name:
BDBM77092
Synonyms:
CMX-157 | CMX157 | HDP-tenofovir | Tenofovir Exalidex | hexadecyloxypropyl 9-(2-(phosphonomethoxy)propyl)adenine
Type:
Small organic molecule
Emp. Form.:
C28H52N5O5P
Mol. Mass.:
569.7167
SMILES:
CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](C)Cn1cnc2c(N)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: