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Target
D-aspartate oxidase
Ligand
BDBM31164
Substrate
BDBM31174
Meas. Tech.
DAAO in Vitro Activity Assay
IC50
>7640±n/a nM
Citation
 Duplantier, AJ; Becker, SL; Bohanon, MJ; Borzilleri, KA; Chrunyk, BA; Downs, JT; Hu, LY; El-Kattan, A; James, LC; Liu, S; Lu, J; Maklad, N; Mansour, MN; Mente, S; Piotrowski, MA; Sakya, SM; Sheehan, S; Steyn, SJ; Strick, CA; Williams, VA; Zhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem 52:3576-85 (2009) [PubMed]  Article 
Target
Name:
D-aspartate oxidase
Synonyms:
D-Aspartate Oxidase (DDO) | DASOX | DDO | OXDD_HUMAN
Type:
Oxidoreductase
Mol. Mass.:
37543.06
Organism:
Homo sapiens (Human)
Description:
Recombinant human DDO expressed and purified from sf9 insect cells, was used in enzyme assays.
Residue:
341
Sequence:
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
  
Inhibitor
Name:
BDBM31164
Synonyms:
naphthyridinone analog.,18
Type:
Small organic molecule
Emp. Form.:
C8H6N2O2
Mol. Mass.:
162.1454
SMILES:
Oc1cc2cccnc2[nH]c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM31174
Synonyms:
CHEMBL29757 | D-Aspartate | D-Aspartic Acid
Type:
Amino Acid
Emp. Form.:
C4H7NO4
Mol. Mass.:
133.1027
SMILES:
N[C@H](CC(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: