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Target
D-amino-acid oxidase
Ligand
BDBM31147
Substrate
BDBM23167
Meas. Tech.
DAAO in Vitro Activity Assay
IC50
424±n/a nM
Citation
 Duplantier, AJ; Becker, SL; Bohanon, MJ; Borzilleri, KA; Chrunyk, BA; Downs, JT; Hu, LY; El-Kattan, A; James, LC; Liu, S; Lu, J; Maklad, N; Mansour, MN; Mente, S; Piotrowski, MA; Sakya, SM; Sheehan, S; Steyn, SJ; Strick, CA; Williams, VA; Zhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem 52:3576-85 (2009) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-Amino Acid Oxidase (DAAO) | DAMOX | Dao | Dao1 | OXDA_RAT
Type:
Homodimer
Mol. Mass.:
38824.91
Organism:
Rattus norvegicus (rat)
Description:
Recombinant rat DAAO expressed and purified from sf9 insect cells, was used in enzyme assays.
Residue:
346
Sequence:
MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSELDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL
  
Inhibitor
Name:
BDBM31147
Synonyms:
4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carboxyfuro[3,2-b]pyrrole, 1 | CHEMBL492591
Type:
Small organic molecule
Emp. Form.:
C7H5NO3
Mol. Mass.:
151.1195
SMILES:
OC(=O)c1cc2occc2[nH]1
Structure:
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Substrate
Name:
BDBM23167
Synonyms:
(2R)-2-amino-3-hydroxypropanoic acid | CHEMBL285123 | D-Serine
Type:
Amino Acid
Emp. Form.:
C3H7NO3
Mol. Mass.:
105.0926
SMILES:
N[C@H](CO)C(O)=O
Structure:
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