Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM397088
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
IC50
1.20±n/a nM
Citation
 Teegarden, B; Chapman, D; Choi, J; Feichtinger, K; Han, S; Jayakumar, H; Tran, T; Xu, J; Zou, N Primary amines and derivitves thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto US Patent  US9987252 Publication Date 6/5/2018 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM397088
Synonyms:
4-Bromo-thiophene-2- carboxylic acid [4-(2- amino-ethoxy)-3-(4- chloro-2-methyl-2H- pyrazol-3-yl)-phenyl]- amide | US9987252, 77
Type:
Small organic molecule
Emp. Form.:
C17H16BrClN4O2S
Mol. Mass.:
455.757
SMILES:
Cn1ncc(Cl)c1-c1cc(NC(=O)c2cc(Br)cs2)ccc1OCCN |(6.95,.27,;6.18,-1.06,;7.09,-2.31,;6.18,-3.56,;4.72,-3.08,;3.38,-3.85,;4.72,-1.54,;3.38,-.77,;2.05,-1.54,;.72,-.77,;-.62,-1.54,;-1.95,-.77,;-1.95,.77,;-3.28,-1.54,;-4.75,-1.06,;-5.65,-2.31,;-7.14,-1.91,;-4.75,-3.56,;-3.28,-3.08,;.72,.77,;2.05,1.54,;3.38,.77,;4.72,1.54,;4.72,3.08,;6.05,3.85,;7.14,2.76,)|
Structure:
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