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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM31197
Substrate/CompetitorPMDM6-F Peptide
Meas. Tech.Fluorescence Polarization-Based (FP-Based) Binding Assay
pH7.5±n/a
Temperature296.15±n/a K
Ki 36±9 nM
Citation Lu, YNikolovska-Coleska, ZFang, XGao, WShangary, SQiu, SQin, DWang, S Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem49:3759-62 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (human)
Description:n/a
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM31197
NameBDBM31197
Synonyms:CHEMBL211045 | Nutlin-3
TypeSmall organic molecule
Emp. Form.C30H30Cl2N4O4
Mol. Mass.581.49
SMILESCOc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |t:6|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
PMDM6-F Peptide
Name:PMDM6-F Peptide
Synonyms:n/a
Type:Fluorescence probe
Mol. Mass.:4802.47
Organism:n/a
Description:n/a
Residue:45
Sequence:
5-FAM-betaAla-betaAla-Phe-Met-Aib-pTyr-(6-Cl-L-Trp)-Glu-Ac3c
-Leu-Asn-NH2