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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM31273
Substrate
biotinylated p53-derived peptide
Meas. Tech.
p53-MDM2 Binding ELISA
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
206000±n/a nM
Citation
 Stoll, R; Renner, C; Hansen, S; Palme, S; Klein, C; Belling, A; Zeslawski, W; Kamionka, M; Rehm, T; Mühlhahn, P; Schumacher, R; Hesse, F; Kaluza, B; Voelter, W; Engh, RA; Holak, TA Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. Biochemistry 40:336-44 (2001) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM31273
Synonyms:
Chalcone derivative, A
Type:
Small organic molecule
Emp. Form.:
C17H13ClO4
Mol. Mass.:
316.736
SMILES:
OC(=O)COc1ccc(\C=C\C(=O)c2ccc(Cl)cc2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
biotinylated p53-derived peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1500.70
Organism:
n/a
Description:
n/a
Residue:
11
Sequence:
MPRFMDYWEDL