Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM397086
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
545±n/a nM
Citation
 Kuduk, SD; Liverton, N; Reger, TS; Skudlarek, JW 5,5-bicyclic oxazole orexin receptor antagonists US Patent  US9987255 Publication Date 6/5/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM397086
Synonyms:
2-(2-{5-[(2-Ethoxypyridin-3-yl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-5-methyl-1,3-oxazol-4-yl)propan-2-ol | US9987255, 2
Type:
Small organic molecule
Emp. Form.:
C21H28N4O4
Mol. Mass.:
400.4714
SMILES:
CCOc1ncccc1C(=O)N1CC2CN(CC2C1)c1nc(c(C)o1)C(C)(C)O
Structure:
Search PDB for entries with ligand similarity: