Target

Ligand

Substrate

Meas. Tech.

AKT IMAP Fluorescence Polarization Assay

pH

7.2±n/a

Temperature

296.15±n/a K

Citation

 Kayser-Bricker, KJ; Glenn, MP; Lee, SH; Sebti, SM; Cheng, JQ; Hamilton, AD Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents. Bioorg Med Chem 17:1764-71 (2009) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

RAC-alpha serine/threonine-protein kinase

Synonyms:

AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)

Type:

Enzyme

Mol. Mass.:

55681.25

Organism:

Homo sapiens (Human)

Description:

P31749

Residue:

480

Sequence:

MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM31442

Synonyms:

phenylaminoethyl guanidine deriv., 21bg

Type:

Small organic molecule

Emp. Form.:

C42H48N6O

Mol. Mass.:

652.8701

SMILES:

CC(C)c1ccc(CN(Cc2ccc(cc2)C(C)C)c2ccc(NC(=O)c3ccc(NCCNC(N)=N)c(c3)-c3ccccc3)cc2)cc1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

Crosstide

Synonyms:

n/a

Type:

5-FAM LABELED PEPTIDE

Mol. Mass.:

1755.47

Organism:

n/a

Description:

n/a

Residue:

16

Sequence:

FAMGRPRTSSFAEGCH