Target

Ligand

Substrate

Meas. Tech.

TF-FVIIa Enzyme Inhibition Assay

pH

7.2±n/a

Temperature

296.15±n/a K

Citation

 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores. Bioorg Med Chem 17:3934-58 (2009) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Coagulation factor VII

Synonyms:

Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator

Type:

Enzyme

Mol. Mass.:

51599.89

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

466

Sequence:

MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM31479

Synonyms:

substituted biphenyl derivative, 36s

Type:

Small organic molecule

Emp. Form.:

C28H30N4O6

Mol. Mass.:

518.561

SMILES:

CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C(O)CO

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

Spectrozyme-FVIIa

Synonyms:

CH3SO2-D-CHA-But-Arg-pNA.AcOH | methanesulphonyl- D-cyclohexylalanyl-butyl-arginine p-nitroanilide acetate

Type:

Chromogenic peptide substrate

Mol. Mass.:

358.43

Organism:

n/a

Description:

n/a

Residue:

3

Sequence:

NA