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Target
Receptor-type tyrosine-protein kinase FLT3 [D835Y]
Ligand
BDBM397418
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
<1±n/a nM
Citation
 Naoe, T; Kiyoi, H; Hagiwara, S; Takasaki, M; Hirano, D; Nakatani, T; Yamaura, T Pharmaceutical composition for treating FLT3 mutation-positive cancer, mutant FLT3 inhibitor and uses thereof US Patent  US9987278 Publication Date 6/5/2018 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [D835Y]
Synonyms:
CD135 | FL cytokine receptor | FLK2 | FLT3 | FLT3(D835Y) | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 (D835Y) | STK-1 | STK1 | Stem cell tyrosine kinase 1 | Tyrosine Kinase FLT3 Mutant (D835Y)
Type:
n/a
Mol. Mass.:
112937.71
Organism:
Homo sapiens (Human)
Description:
P36888 D835Y
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARYIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM397418
Synonyms:
US9987278, Compound Reference 28
Type:
Small organic molecule
Emp. Form.:
C33H39N9O3
Mol. Mass.:
609.7213
SMILES:
CCCNc1nc(Nc2ccc3cnccc3c2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1 |r|
Structure:
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