Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM397492
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay
Ki
30±n/a nM
Citation
 Bartáné Szalai, G; Wágner, GA; Kiss, B; Schmidt, null; Balázs, O; Nagy, N H3 antagonists containing phenoxypiperidine core structure US Patent  US9994525 Publication Date 6/12/2018 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM397492
Synonyms:
US9994525, Example 7
Type:
Small organic molecule
Emp. Form.:
C22H35N3O3
Mol. Mass.:
389.5316
SMILES:
CCNC(=O)N1CCC(CC1)Oc1ccc(OCCCN2CCCCC2)cc1
Structure:
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