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Target
Aurora kinase A
Ligand
BDBM31841
Substrate
Histone H3 (aa 1-18)
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
13±n/a nM
Citation
 Aliagas-Martin, I; Burdick, D; Corson, L; Dotson, J; Drummond, J; Fields, C; Huang, OW; Hunsaker, T; Kleinheinz, T; Krueger, E; Liang, J; Moffat, J; Phillips, G; Pulk, R; Rawson, TE; Ultsch, M; Walker, L; Wiesmann, C; Zhang, B; Zhu, BY; Cochran, AG A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem 52:3300-7 (2009) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM31841
Synonyms:
2,4-Bisanilinopyrimidine, 48
Type:
Small organic molecule
Emp. Form.:
C23H18FN5O3
Mol. Mass.:
431.4191
SMILES:
Oc1ccc(NC(=O)c2ccc(Nc3nc(Nc4ccc(O)cc4)ncc3F)cc2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone H3 (aa 1-18)
Synonyms:
GST fusion of N-terminus of Histone H3 (aa 1-18) | H31_HUMAN | H3C1 | H3FA | H3FB | H3FC HIST1H3C | H3FD | H3FF | H3FH | H3FI | H3FJ | H3FK | H3FL | HIST1H3A | HIST1H3B | HIST1H3D | HIST1H3E | HIST1H3F | HIST1H3G | HIST1H3H | HIST1H3I | HIST1H3J | Histone H3
Type:
Peptide
Mol. Mass.:
1951.30
Organism:
Homo sapiens (Human)
Description:
P68431 (aa 1-18)
Residue:
18
Sequence:
MARTKQTARKSTGGKAPR