Target
Cathepsin K
Ligand
BDBM31990
Substrate
BDBM22047
Meas. Tech.
Cathepsin Inhibition Assay
IC50
5012±n/a nM
Citation
 Asaad, NBethel, PACoulson, MDDawson, JEFord, SJGerhardt, SGrist, MHamlin, GAJames, MJJones, EVKaroutchi, GIKenny, PWMorley, ADOldham, KRankine, NRyan, DWells, SLWood, LAugustin, MKrapp, SSimader, HSteinbacher, S Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett 19:4280-3 (2009) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM31990
Synonyms:
Dipeptidyl nitrile inhibitor, 23
Type:
Small organic molecule
Emp. Form.:
C18H20ClN5O2
Mol. Mass.:
373.837
SMILES:
CCc1cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)n(C)n1 |r|
Structure:
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Substrate
Name:
BDBM22047
Synonyms:
CBZ-Phe-Arg 7-amido-4-methylcoumarin | Z-Phe-Arg-AMC
Type:
Fluorogenic substrate
Emp. Form.:
C33H36N6O6
Mol. Mass.:
612.6755
SMILES:
[#6]-c1cc(=O)oc2cc(-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c3ccccc3)-[#7]-[#6](=O)-[#8]-[#6]-c3ccccc3)ccc12
Structure:
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