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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM32013
Substrate
cy3B-GM
Meas. Tech.
Tumor Hsp90 Inhibitors Dose Response Confirmation
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
15120.1±n/a nM
Citation
 PubChem, PC Tumor Hsp90 Inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM32013
Synonyms:
4-Amino-2-(1-oxo-1,2,3,4-tetrahydro-naphthalen-2-ylsulfanyl)-pyrimidine-5-carboxylic acid ethyl ester | 4-amino-2-[(1-ketotetralin-2-yl)thio]pyrimidine-5-carboxylic acid ethyl ester | 4-amino-2-[(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)thio]-5-pyrimidinecarboxylic acid ethyl ester | MLS000029104 | SMR000001871 | cid_655515 | ethyl 4-amino-2-[(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)sulfanyl]pyrimidine-5-carboxylate | ethyl 4-azanyl-2-[(1-oxidanylidene-3,4-dihydro-2H-naphthalen-2-yl)sulfanyl]pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H17N3O3S
Mol. Mass.:
343.4
SMILES:
CCOC(=O)c1cnc(SC2CCc3ccccc3C2=O)nc1N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
cy3B-GM
Synonyms:
fluorescently (Cy3B) labeled geldanamycin
Type:
fluorescent probe
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA