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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Ligand
BDBM32262
Substrate
F-Bim
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
20620±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. PubChem Bioassay (2008)[AID] 
Target
Name:
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:
B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:
Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:
26053.63
Organism:
Homo sapiens (Human)
Description:
gi_510901
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM32262
Synonyms:
5-benzyl-8-methyl-3-(methylthio)-[1,2,4]triazin[5,6-b]indole | 5-benzyl-8-methyl-3-methylsulfanyl-[1,2,4]triazino[5,6-b]indole | 8-methyl-3-(methylthio)-5-(phenylmethyl)-[1,2,4]triazino[5,6-b]indole | 8-methyl-3-methylsulfanyl-5-(phenylmethyl)-[1,2,4]triazino[5,6-b]indole | MLS000042505 | SMR000046397 | cid_6400963
Type:
Small organic molecule
Emp. Form.:
C18H16N4S
Mol. Mass.:
320.411
SMILES:
CSc1nnc2c3cc(C)ccc3n(Cc3ccccc3)c2n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
F-Bim
Synonyms:
n/a
Type:
fluorescent peptide probe
Mol. Mass.:
3923.40
Organism:
n/a
Description:
n/a
Residue:
32
Sequence:
FITCAHDMRPEIWIAQELRRIGDEFNAYYARH