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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Ligand
BDBM32297
Substrate
F-Bim
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
18370±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. PubChem Bioassay (2008)[AID] 
Target
Name:
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:
B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:
Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:
26053.63
Organism:
Homo sapiens (Human)
Description:
gi_510901
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM32297
Synonyms:
MLS000553768 | N-(2-furanylmethyl)-N-[2-[[(E)-(3-methoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]hydrazo]-2-oxoethyl]benzenesulfonamide | N-(2-furfuryl)-N-[2-keto-2-[N'-[(E)-(4-keto-3-methoxy-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazino]ethyl]benzenesulfonamide | N-(furan-2-ylmethyl)-N-[2-[2-[(E)-(3-methoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazinyl]-2-oxidanylidene-ethyl]benzenesulfonamide | N-(furan-2-ylmethyl)-N-[2-[2-[(E)-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]hydrazinyl]-2-oxoethyl]benzenesulfonamide | N-Furan-2-ylmethyl-N-(4-hydroxy-3-methoxy-benzylidene-hydrazinocarbonylmethyl)-benzenesulfonamide | SMR000171926 | cid_5763241
Type:
Small organic molecule
Emp. Form.:
C21H21N3O6S
Mol. Mass.:
443.473
SMILES:
COc1cc(C=NNC(=O)CN(Cc2ccco2)S(=O)(=O)c2ccccc2)ccc1O |w:6.6|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
F-Bim
Synonyms:
n/a
Type:
fluorescent peptide probe
Mol. Mass.:
3923.40
Organism:
n/a
Description:
n/a
Residue:
32
Sequence:
FITCAHDMRPEIWIAQELRRIGDEFNAYYARH