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TargetHeat Shock 70kDa Protein 1
LigandBDBM2
Substrate/CompetitorBDBM32369
Meas. Tech.HSP70 Fluorescence Polarization Assay
pH7.4±n/a
Temperature296.15±n/a K
IC50 500±n/a nM
Citation Williamson, DSBorgognoni, JClay, ADaniels, ZDokurno, PDrysdale, MJFoloppe, NFrancis, GLGraham, CJHowes, RMacias, ATMurray, JBParsons, RShaw, TSurgenor, AETerry, LWang, YWood, MMassey, AJ Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. J Med Chem52:1510-3 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Heat Shock 70kDa Protein 1
Name:Heat shock 70 kDa protein 1A/1B
Synonyms:HSP70-1/HSP70-2 | HSP70.1 | Hsp70
Type:Chaperone
Mol. Mass.:70043.82
Organism:Homo sapiens (Human)
Description:n/a
Residue:641
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
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BDBM2
NameBDBM2
Synonyms:({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid | ATP | Brimonidine ATP | CHEMBL14249
TypeNucleoside or nucleotide
Emp. Form.C10H16N5O13P3
Mol. Mass.507.181
SMILESNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure
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BDBM32369
NameBDBM32369
Synonyms:N6-(6-amino)hexyl-ATP-5-FAM
Typefluorescein-labeled ATP-based probe
Emp. Form.C38H38N6O18P3
Mol. Mass.959.6607
SMILESO[C@@H]1[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O[C@H]([C@@H]1O)n1cnc2c(NCCCCCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Cc4cc(O)ccc34)ncnc12 |r|
Structure
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