Reaction Details Report a problem with these data
Target
Interleukin-1 beta
Ligand
BDBM398203
Substrate
n/a
Meas. Tech.
IL-1beta release assay
IC50
55±n/a nM
Citation
 Karra, SR Indole derivatives and their use in neurodegenerative diseases US Patent  US10323000 Publication Date 6/18/2019 
Target
Name:
Interleukin-1 beta
Synonyms:
IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta
Type:
Cytokine
Mol. Mass.:
30734.47
Organism:
Homo sapiens (Human)
Description:
P01584
Residue:
269
Sequence:
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
  
Inhibitor
Name:
BDBM398203
Synonyms:
4-chloro-N-(((1S,3S)-1-hydroxy-3-methylcyclohexyl) methyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-indole-3-carboxamide | US10323000, Compound 140 | US10676433, Compound 140
Type:
Small organic molecule
Emp. Form.:
C22H29ClN2O3
Mol. Mass.:
404.93
SMILES:
C[C@H]1CCC[C@@](O)(CNC(=O)c2cn(CC3CCCO3)c3cccc(Cl)c23)C1 |r|
Structure:
Search PDB for entries with ligand similarity: