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Target
Interleukin-1 beta
Ligand
BDBM398212
Substrate
n/a
Meas. Tech.
IL-1beta release assay
IC50
55±n/a nM
Citation
 Karra, SR Indole derivatives and their use in neurodegenerative diseases US Patent  US10323000 Publication Date 6/18/2019 
Target
Name:
Interleukin-1 beta
Synonyms:
IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta
Type:
Cytokine
Mol. Mass.:
30734.47
Organism:
Homo sapiens (Human)
Description:
P01584
Residue:
269
Sequence:
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
  
Inhibitor
Name:
BDBM398212
Synonyms:
1-((1,4-dioxan-2-yl)methyl)-4-chloro-N-((4,4-difluorocyclohexyl)methyl)-1H-indole-3-carboxamide | US10323000, Compound 150 | US10676433, Compound 150
Type:
Small organic molecule
Emp. Form.:
C21H25ClF2N2O3
Mol. Mass.:
426.885
SMILES:
FC1(F)CCC(CNC(=O)c2cn(CC3COCCO3)c3cccc(Cl)c23)CC1
Structure:
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