Reaction Details Report a problem with these data
Target
3-phosphoinositide-dependent protein kinase 1 [48-359]
Ligand
BDBM32432
Substrate
Serine/threonine-protein kinase Sgk1
Meas. Tech.
ELISA assay
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
146±n/a nM
Citation
 Kim, KH; Wissner, A; Floyd, MB; Fraser, HL; Wang, YD; Dushin, RG; Hu, Y; Olland, A; Guo, B; Arndt, K Benzo[c][2,7]naphthyridines as inhibitors of PDK-1. Bioorg Med Chem Lett 19:5225-8 (2009) [PubMed]  Article 
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [48-359]
Synonyms:
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | hPDK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
35527.50
Organism:
Homo sapiens (Human)
Description:
O15530[48-359]
Residue:
312
Sequence:
GPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLT
  
Inhibitor
Name:
BDBM32432
Synonyms:
Benzo[c][2,7]naphthyridine, 26
Type:
Small organic molecule
Emp. Form.:
C25H20N4O2
Mol. Mass.:
408.4519
SMILES:
COc1cc2c(cc1OCc1ccccc1)ncc1c(N)nc(cc21)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL