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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM398498
Substrate
n/a
Meas. Tech.
NAMPT Enzyme Assay
IC50
<10±n/a nM
Citation
 Freeze, BS; Gigstad, KM; Janowick, DA; Lee, HM; Shi, Z; Soucy, F; Vyskocil, S Quinazoline and quinoline compounds and uses thereof US Patent  US10323018 Publication Date 6/18/2019 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM398498
Synonyms:
US10323018, Compound I-227
Type:
Small organic molecule
Emp. Form.:
C27H26FN3O2
Mol. Mass.:
443.5126
SMILES:
CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1ccc(C)nc1)-c1ccc(F)cc1
Structure:
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