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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
Ligand
BDBM32635
Substrate
BDBM32618
Meas. Tech.
Screening Assay for ABCG2 Inhibitors
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
5400±n/a nM
Citation
 Henrich, CJ; Robey, RW; Bokesch, HR; Bates, SE; Shukla, S; Ambudkar, SV; Dean, M; McMahon, JB New inhibitors of ABCG2 identified by high-throughput screening. Mol Cancer Ther 6:3271-8 (2007) [PubMed]  Article 
Target
Name:
Broad substrate specificity ATP-binding cassette transporter ABCG2
Synonyms:
ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter
Type:
Multi-pass membrane protein; monomer or homodimer; disulfide-linked
Mol. Mass.:
72329.48
Organism:
Homo sapiens (Human)
Description:
Q9UNQ0
Residue:
655
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
  
Inhibitor
Name:
BDBM32635
Synonyms:
NSC306698
Type:
Small organic molecule
Emp. Form.:
C19H18NO2
Mol. Mass.:
292.3512
SMILES:
Cc1ccc(NC(=[OH+])c2cc3ccccc3cc2O)c(C)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM32618
Synonyms:
NSC75783 | PhA | pheophorbide a
Type:
n/a
Emp. Form.:
C35H36N4O5
Mol. Mass.:
592.6841
SMILES:
CCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(O)=O)[C@@H]4C)c4c(C(=O)OC)c(O)c5c(C)c(cc1[nH]2)nc45)c(C)c3C=C
Structure:
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