Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33124
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
360±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33124
Synonyms:
2-Chloro-3-[4-(2-nitro-phenyl)-piperazin-1-yl]-[1,4]naphthoquinone | 2-chloranyl-3-[4-(2-nitrophenyl)piperazin-1-yl]naphthalene-1,4-dione | 2-chloro-3-[4-(2-nitrophenyl)-1-piperazinyl]naphthalene-1,4-dione | 2-chloro-3-[4-(2-nitrophenyl)piperazin-1-yl]naphthalene-1,4-dione | 2-chloro-3-[4-(2-nitrophenyl)piperazino]-1,4-naphthoquinone | MLS000588199 | SMR000220218 | cid_4561725
Type:
Small organic molecule
Emp. Form.:
C20H16ClN3O4
Mol. Mass.:
397.812
SMILES:
[O-][N+](=O)c1ccccc1N1CCN(CC1)C1=C(Cl)C(=O)c2ccccc2C1=O |c:17|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR