Target

Ligand

Substrate

Meas. Tech.

CHK1 AlphaScreen

pH

7.5±n/a

Temperature

296.15±n/a K

Citation

 Matthews, TP; Klair, S; Burns, S; Boxall, K; Cherry, M; Fisher, M; Westwood, IM; Walton, MI; McHardy, T; Cheung, KM; Van Montfort, R; Williams, D; Aherne, GW; Garrett, MD; Reader, J; Collins, I Identification of inhibitors of checkpoint kinase 1 through template screening. J Med Chem 52:4810-9 (2009) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Serine/threonine-protein kinase Chk1

Synonyms:

CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

54443.02

Organism:

Homo sapiens (Human)

Description:

gi_166295192

Residue:

476

Sequence:

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM33202

Synonyms:

benzisoxazole, 1

Type:

Small organic molecule

Emp. Form.:

C16H10FN3O

Mol. Mass.:

279.2685

SMILES:

Fc1ccc(cc1)-c1onc2ccc(cc12)-c1cc[nH]n1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

biotinylated CHKtide

Synonyms:

n/a

Type:

biotinylated peptide

Mol. Mass.:

3148.69

Organism:

n/a

Description:

n/a

Residue:

27

Sequence:

ITINKKKVSRSGLYRSPSMPENLNRPR