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Target
Non-receptor tyrosine-protein kinase TYK2 [V731I]
Ligand
BDBM399746
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
0.3±n/a nM
Citation
 Greenwood, JR; Harriman, GC; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent  US10323036 Publication Date 6/18/2019 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [V731I]
Synonyms:
JH2 domain (V731I) | TYK2 | TYK2 (V731I) | TYK2_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
133680.06
Organism:
Homo sapiens (Human)
Description:
P29597[V731I]
Residue:
1187
Sequence:
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLIHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM399746
Synonyms:
US10323036, Compound I-235 | US10793574, Compound I-235 | US11220508, Compound I-235
Type:
Small organic molecule
Emp. Form.:
C20H21F3N6O4S
Mol. Mass.:
498.479
SMILES:
CN(c1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)C(F)(F)F)S(C)(=O)=O
Structure:
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