Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM399788
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Jones, TK; Duncan, KK; Cisar, JS; Merit, JE; Weber, OD Pyrazole compounds and methods of making and using same US Patent  US10323038 Publication Date 6/18/2019 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM399788
Synonyms:
N-(1-(5-(2-chloro-4- morpholinobenzyl)octahydropyrrolo[3,4- c]pyrrole-2-carbonyl)-1H-pyrazol-4-yl)- N-methylacetamide | US10323038, Example 16
Type:
Small organic molecule
Emp. Form.:
C24H31ClN6O3
Mol. Mass.:
486.994
SMILES:
CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc(cc3Cl)N3CCOCC3)CC2C1
Structure:
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