Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM107709
Substrate
n/a
Meas. Tech.
EGLN-1 Activity Assay
IC50
1600±n/a nM
Citation
Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent USRE47437 Publication Date 6/18/2019
More Info.:
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
Inhibitor
Name:
BDBM107709
Synonyms:
US11426393, Compound Table XV.15 | US8598210, Table XV, 15 | US8722895, 15: {[5-(4-Isopropoxyphenyl)-3- hydroxypyridine-2-carbonyl]amino}-acetic acid | US9598370, Example 00140 | USRE47437, Example {[5-(4-Isopropoxyphenyl)-3-hydroxypyridine-2-carbonyl]amino}-aceticacid
Type:
Small organic molecule
Emp. Form.:
C17H18N2O5
Mol. Mass.:
330.3352
SMILES:
CC(C)Oc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1