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Target
Egl nine homolog 1
Ligand
BDBM107717
Substrate
n/a
Meas. Tech.
EGLN-1 Activity Assay
IC50
300±n/a nM
Citation
 Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent  USRE47437 Publication Date 6/18/2019 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM107717
Synonyms:
US11426393, Compound Table XV.23 | US8598210, Table XV, 23 | US8722895, 23: ({3-Hydroxy-5-[3-(pyrrolidine-1- carbonyl)phenyl]-pyridine-2- carbonyl}amino)-acetic acid | US9598370, Example 00148 | USRE47437, Example ({3-Hydroxy-5-[3-(pyrrolidine-1-carbonyl)phenyl]-pyridine-2-carbonyl}amino)-acetic acid
Type:
Small organic molecule
Emp. Form.:
C19H19N3O5
Mol. Mass.:
369.3713
SMILES:
OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Structure:
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