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Target
Sodium/bile acid cotransporter
Ligand
BDBM400068
Substrate
n/a
Meas. Tech.
HBV DNA Quantification Assay
EC50
264±n/a nM
Citation
 Du, J; Kaplan, JA; Kirschberg, TA; Kobayashi, T; Lazerwith, SE; Lee, RA; Medley, JW; Mitchell, ML; Morganelli, PA; Pyun, H; Shevick, SL; Squires, NH; Watkins, WJ Substituted pyrrolizine compounds and uses thereof US Patent  US10328053 Publication Date 6/25/2019 
Target
Name:
Sodium/bile acid cotransporter
Synonyms:
Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1
Type:
PROTEIN
Mol. Mass.:
38131.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_838517
Residue:
349
Sequence:
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
  
Inhibitor
Name:
BDBM400068
Synonyms:
(S)-7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)-2-oxoacetyl)-N-(3-chloro-4-fluorophenyl)-2-fluoro-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide | US10328053, Compound 46 | US10874640, Compound 46 | US20230270719, Compound 46
Type:
Small organic molecule
Emp. Form.:
C22H19ClF2N6O3
Mol. Mass.:
488.874
SMILES:
Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2C[C@H](F)Cn2c1C(=O)Nc1ccc(F)c(Cl)c1 |r|
Structure:
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