Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM400286
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<10±n/a nM
Citation
 Huang, TXue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent  US9999619 Publication Date 6/19/2018
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 (aa 837-1142) | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM400286
Synonyms:
US10695337, Example 40 | US11285140, Example 40 | US9999619, Example 41
Type:
Small organic molecule
Emp. Form.:
C27H27FN8O2
Mol. Mass.:
514.5541
SMILES:
COc1cc(F)ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
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