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Target
Serine/threonine-protein kinase Chk2 [209-531,Q209M]
Ligand
BDBM34069
Substrate
Fam-CHK2tide
Meas. Tech.
IMAP High-Throughput Screening
pH
7.2±n/a
Temperature
296.15±n/a K
IC50
>20000±n/a nM
Citation
 Jobson, AG; Cardellina, JH; Scudiero, D; Kondapaka, S; Zhang, H; Kim, H; Shoemaker, R; Pommier, Y Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol Pharmacol 72:876-84 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk2 [209-531,Q209M]
Synonyms:
CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | Checkpoint Kinase 2 | RAD53
Type:
Serine/threonine-protein kinase
Mol. Mass.:
36511.81
Organism:
Homo sapiens (Human)
Description:
O96017[209-531,Q209M]
Residue:
323
Sequence:
MSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAE
  
Inhibitor
Name:
BDBM34069
Synonyms:
NSC 177940
Type:
Small organic molecule
Emp. Form.:
C16H18N6S
Mol. Mass.:
326.419
SMILES:
[#6]-[#6](=[#7]\[#7]=[#6](/[#7])-[#7])-c1ccc(-[#7]-[#6](=S)-[#7]-c2ccccc2)cc1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fam-CHK2tide
Synonyms:
n/a
Type:
fluorescent-labeled peptide
Mol. Mass.:
2356.22
Organism:
n/a
Description:
n/a
Residue:
19
Sequence:
FAMAMRLERQDSIFYPKNH