Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetG-protein coupled receptor 6
LigandBDBM382113
Substrate/Competitorn/a
Meas. Tech.Inhibition of cAMP Activity of GPR6 In Vitro Assay
EC50 30200±n/a nM
Citation Adams, MEBrown, JWHitchcock, SHopkins, MKikuchi, SLam, BMonenschein, HReichard, HSun, H Pyrazines as modulators of GPR6 US Patent US10000468 Publication Date 6/19/2018
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled receptor 6
Name:G-protein coupled receptor 6
Synonyms:G-protein coupled receptor 6 (GPR6) | GPR6 | Sphingosine 1-phosphate receptor GPR6
Type:Protein
Mol. Mass.:37886.39
Organism:Homo sapiens (Human)
Description:P46095
Residue:362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM382113
NameBDBM382113
Synonyms:(S)-6-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-5-(isopropylamino)-N-methylpyrazine-2-carboxamide | US10000468, Example 22 | US10273225, Example 22
TypeSmall organic molecule
Emp. Form.C21H26F3N5O
Mol. Mass.421.4592
SMILESCNC(=O)c1cnc(NC(C)C)c(n1)N1CCC(CC1)[C@H](F)c1ccc(F)cc1F |r|
Structure
n/a