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TargetG-protein coupled receptor 6
LigandBDBM382117
Substrate/Competitorn/a
Meas. Tech.Inhibition of cAMP Activity of GPR6 In Vitro Assay
EC50 72300±n/a nM
Citation Adams, MEBrown, JWHitchcock, SHopkins, MKikuchi, SLam, BMonenschein, HReichard, HSun, H Pyrazines as modulators of GPR6 US Patent US10000468 Publication Date 6/19/2018
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled receptor 6
Name:G-protein coupled receptor 6
Synonyms:G-protein coupled receptor 6 (GPR6) | GPR6 | Sphingosine 1-phosphate receptor GPR6
Type:Protein
Mol. Mass.:37886.39
Organism:Homo sapiens (Human)
Description:P46095
Residue:362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM382117
NameBDBM382117
Synonyms:US10000468, Example 26 | US10273225, Example 26
TypeSmall organic molecule
Emp. Form.C20H20F3N5
Mol. Mass.387.4015
SMILESF[C@H](C1CCN(CC1)c1nc(cnc1NC1CC1)C#N)c1ccc(F)cc1F |r|
Structure
n/a