Reaction Details Report a problem with these data
Target
Mannose-6-phosphate isomerase
Ligand
BDBM34570
Substrate
Mannose-6-phosphate
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
>50000±0 nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34570
Synonyms:
MLS000034355 | N-tert-Butyl-2-{2-methoxy-4-[(2-oxo-2,3-dihydro-1H-benzoimidazol-5-ylamino)-methyl]-phenoxy}-acetamide | N-tert-butyl-2-[2-methoxy-4-[[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)amino]methyl]phenoxy]ethanamide | N-tert-butyl-2-[2-methoxy-4-[[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]methyl]phenoxy]acetamide | N-tert-butyl-2-[4-[[(2-keto-1,3-dihydrobenzimidazol-5-yl)amino]methyl]-2-methoxy-phenoxy]acetamide | SMR000014151 | cid_655834
Type:
Small organic molecule
Emp. Form.:
C21H26N4O4
Mol. Mass.:
398.4555
SMILES:
COc1cc(CNc2ccc3[nH]c(=O)[nH]c3c2)ccc1OCC(=O)NC(C)(C)C
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Mannose-6-phosphate
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA