Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM34997
Substrate
Biotinylated Substrate Peptide
Meas. Tech.
Pim Kinase Assay
pH
7.5±n/a
Temperature
296.15±n/a K
Ki
0.9±n/a nM
Citation
 Tao, ZFHasvold, LALeverson, JDHan, EKGuan, RJohnson, EFStoll, VSStewart, KDStamper, GSoni, NBouska, JJLuo, YSowin, TJLin, NHGiranda, VSRosenberg, SHPenning, TD Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases. J Med Chem 52:6621-36 (2009) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM34997
Synonyms:
benzothienopyrimidinone deriv., 6n
Type:
Small organic molecule
Emp. Form.:
C17H12ClN3O2S
Mol. Mass.:
357.814
SMILES:
Oc1cccc(NCc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Ryanodine receptor 1 [4317-4329]
Synonyms:
Biotinylated Substrate Peptide | RYDR | RYR1 | RYR1_HUMAN
Type:
Peptide
Mol. Mass.:
2871.44
Organism:
n/a
Description:
P21817[4317-4329]
Residue:
24
Sequence:
ITINCLINKERVRRLRRLTAREAA